Dhuvarakesh Karthikeyan
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THESIS Multiscale Modeling of the Adaptive Immune Response
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Lymph node cross-section, with an inset showing an antigen-presenting cell meeting a CD8 T cell
Spleen cross-section showing red pulp, white pulp and white blood cells
Thymus cross-section: cortex, positive selection; medulla, negative selection Thymus with a magnified cross-section: cortex, positive selection; medulla, negative selection
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The adaptive immune response starts with self-nonself determination at the molecular resolution, is executed through the concerted behavior of individual cells, and ultimately becomes a coordinated response across tissues and the whole body, spanning vast space and time scales.

Click through to learn about how this multi-scale response unfolds and explore some of my work modeling this incredible system.
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My work here
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Thymus · 4.5 cm
Bone marrow · 45 cm
Arteries & veins · 90 cm
Lymph nodes · 1.2 cm
Spleen · 12 cm
T cell : APC · 15 µm
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Hi, my name’s Dhuvi

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Check out my work → Skip
Happy to chat immune receptor modelling, immunogenicity prediction, or anything at the interface of the two (i.e. personalized medicine).
dkarthikeyan1@unc.edu